Neurological Clinical Symptoms and CT Scan Brain Images of Non Small Cell Lung Carcinoma Patients With Brain Metastasis In Persahabatan Hospital

Dian Yulianti, Elisna Syahruddin, Achmad Hudoyo, Aziza Icksan

Abstract


Background. Brain is one of the common sites of distant metastasis in patients of lung cancer, and incidens
of brain metastasis in lung cancer is considered high. In Non-small Cell lung cancer guide line, brain CT done
if the neurological symptoms occured. Therefore analysis of diagnostic approach related to brain metastases
is needed.
Methods. Prospective analysis of 35 patients newly diagnosed cases of brain metastases in NSCLC. Cross
sectional study with additional analysis to find relationship of clinical symptom to result of CT brain over periode
July 2008-August 2009 in Persahabatan Hospital. Data were analysed as regards to the presence/absence of
neurogical symtomps. Prognostic approach was applied to analyze survival rate.
Results. We found that 85,7% patients brain metastases with neurological symptomatic and 14,3%
asymptomatic. Five (14,3%) patients with more than one neurologycal symptoms. Depend on stage and cell
type of which 27 (77,1%) with adenocarcinoma, 21 (62,9%) with T4, 17 (48,6%) N0 and patients with soliter
nodule 8 (22,9%). There’s no correlation between neurologycal symptom and brain metastases. Median
survival time of lung cancer patients with brain metastases are 11 month.
Conclusion. The majority lung cancer patients with brain metastasis have neurological symptoms. The most
brain metatases found in patient with adenocarcinoma, T4 and N0. Median survival was increased in treated
patients
Keywords : Lung cancer, NSCLC, Brain metastases, Neurological symptoms.

References



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