Nasopharyngeal Carcinoma External Radiation As Causal of Sensorineural Hearing Loss

Rakhmat Haryanto, Ongka M. Saefuddin, Thaufiq S. Boesoirie

Abstract


Radiation has an important role on nasopharyngeal carcinoma therapy because surgery is often difficult, however itcause sensorineural hearing loss as side effect. Longitudinal observational study was conducted to know the effect ofradiation on sensorineural hearing loss of nasopharyngeal carcinoma patients at Ear, Nose, and Throat Department,Hasan Sadikin Hospital, February-August 2006. Twenty eight male and 7 female, with no sensorineural hearing lossin one or both ears, age 12–72 years, and met inclusion criteria, were included in this study. All patients receivedradiation and underwent audiometry and tympanometry prior-,during-radiation with a 2.000 cGy and 6,600 cGy, andone month postradiation. Data was analyzed using Chi-square, Mc-Nemar, and exact Fisher test. The results showedthat incidence of sensorineural hearing loss were 7 cases (10%) on 2,000 cGy, 22 cases (31.4%) on 6,600 cGy, and 24cases (34.3%) on postradiation. The relationship between duration 6,600 cGy and 2,000 cGy in the normalpreradiation group were significant (p= 0.001), whereas postradiation and duration with 6,600 cGy was notsignificant (p= 0.5). Sensorineural hearing loss on >30 years was 37.0% on duration 6,600 cGy (p=0.031) and 40.7%postradiation (p=0.018). In conclusion, radiation on nasopharyngeal carcinoma can induce sensorineural hearingloss during- or postradiation and age >30 years is prognostic factor for sensorineural hearing loss.[MKB. 2010;42(3):108-14].

Key words: Nasopharyngeal carcinoma, radiation, sensorineural hearing loss


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