Hepatoprotective Effect of Indian Pennywort Methanol Extract Compare with Vitamin E on Hepatitis Rats Model

Putri Vidyaniati, Armaya Ariyoga, Herri S. Satramihardja

Abstract


Herbal medicine Indian Pennywort (Centella asiatica Linn) is commonly used as alternative therapy for hepatitis.The aim of this study was to evaluate the effect of Indian Pennywort methanol extract on carbontetrachloride (CCl )- 4induced hepatitis rats model, compared with vitamin E. Parameters used were levels of serum glutamic pyruvictransaminase (SGPT), malondialdehide (MDA), and extent of liver necrosis. Experimental laboratory study wasconducted at Pharmacology Laboratory Hasan Sadikin Hospital Bandung, October 2009, with randomized completedesign on 40 rats divided into 8 subgroups. The level of SGPT was analyzed by enzymatic method, MDA level wasanalyzed by Wilbur method. The extent of liver necrosis was analyzed by hematoxylin eosin staining. The results, theextract, if given pre-induction of hepatotoxicity, can significantly prevent the increase of SGPT levels and the extentof necrosis (p ≤0.05), but can't significantly prevent the increase of liver tissue MDA levels (p >0.05). Postinduction,the extract can significantly reduce the SGPT levels, liver tissue MDA levels, and the extent of livernecrosis (p≤0.05). Therefore, effect of the Indian Pennywort extract is better than vitamin E, and can act ashepatoprotector. [MKB. 2010;42(3):101-7].

Key words: Indian pennywort, liver tissue malondialdehide, necrosis , serum glutamic pyruvic transaminase


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