Comparison of The Effectiveness of Methylprednisolone 2 mg/Kg, 10 mg/Kg, 30 mg/Kg to Prevent IL-6’s Increment in Patient with Congenital Heart Disease Undergoing Open Cardiac Surgery

Thariq Emyl Taufik

Abstract


Background: Although there were so many open cardiac surgery on patient with congenital heart disease in RSCM, there were still a few of studies about using methylprednisolone in this case. This study based on the count of IL-6 and not other cytokine because of difficultness in counting and measuring other cytokine such as TNF-α, IL-1, and also IL-8 that depended on temperature.

Methods: This double blinded randomized clinical trial compares effectiveness of several dosage of methylprednisolone for preventing the increasing of IL-6 post open cardiac surgery in congenital heart disease.

Results: Post operative IL-6 increases significantly. Group with the dosage 30 mg/kg showed the smallest increment of IL-6 compared with group with the dosage 2 mg/kg and 10 mg/kg. Several dosages of methylprednisolone not significantly related with inpatient period in ICU (p>0,05).

Conclusions: Methylprednisolone is not able to prevent the increment of IL-6. Dosage is not related with the inpatient period in ICU.

Keywords: Methylprednisolone, IL-6, congenital heart disease, cardiac surgery.


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