Corelation Between Matrix Metalloproteinase-9 (MMP-9) With Complications of Acute Heart Failure In Myocardial Infarction With ST-Elevation (STEMI) And Acute Coronary Syndromes Without STElevation (NSTEACS)

Budi Yuli Setianto, Sofia Mubarika, Bambang Irawan


Background. Acute coronary syndrome (ACS) often leads tocomplications of acute heart failure. These complications will increasethe morbidity and mortality of patients with ACS.Objective. To determine differences in levels of MMP-9 betweenSTEMI and NSTEACS and the correlation between MMP-9 with acuteheart failure between the two groups.Methods. Examination of the samples performed in 79 patientswith ACS (38 STEMI and 41 NSTEACS) prior to the action ofintravenous thrombolytic or coronary intervention. Differences inlevels of MMP-9 in the ACS are experiencing acute heart failure andwithout heart failure, and differences in levels of MMP-9 in the STEMI andNSTEACS groups were tested with Chi-square, Fisher’s exact test or theIndependent t-test.Results. STEMI groups had significantly higher levels of MMP-9 thanNSTEACS group 1629.12 ± 719.60 compared to 1033.42 ± 777.12(p = 0.001). However, STEMI groups who have acuteheart failureare higher but not significant compared with NSTEACS group 14(36.84) and 11 (26.82) (p = 0.339). There are differences in levelsof MMP-9 in ACS with acute heart failure than those who did not:1698 ± 867.95 ng/mL and 1144.61 ± 713.60 ng/mL (p = 0.004).Conclusion. MMP-9 levels are significantly higher in STEMI groupscompared with NSTEACS groups, and MMP-9 associated with the incidenceofacute heart failure in ACS. STEMI groups have tended to have acute heartfailure are higher than NSTEACS groups.


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