Detection of Thalassaemia Carrier Using Capillary Electrophoresis in Banyumas District

Lantip Rujito, Lina Sunayya, Muhammad Basalamah, Joko Setyono, Wahyu Siswandari


Introductions: Thalassaemia is a most prevent  of monogenic hematological diseases in the world’s population. Carrier detection is a very important step for thalassemia prevention  program. Recently, Banyumas has many thalassaemia patients, however not supported by the accurate data about thalassaemia carrier in the general population.
Purpose: Identifying the frequency of thalassemia carrier in the general population of Banyumas.
Method: Cross sectional study using the general population scattered in Banyumas district. Subjects were 183 people with 17-60 years of age criteria, there was no family history of thalassemia and history of hematological diseases. Early detection using HTA criteria in 2010 to assess erythrocyte index, followed by examination of hemoglobin fractions by capillary electrophoresis method.
Results: At first screening using eristrosit index evaluation, study showed that the suspect thalassemia career was 8.2%. Using capillary electrophoresis method further, it was known that b thalassemia and HbE carrier suspect was identified about 6.1%; a thalassaemia or iron deficiency 4,2%; and other variant counted as 1.2%
Conclusion: Thalassemia carrier in Banyumas was quite high with a possible carrier of a  and b  thalassemia trait was 10%.

Keywords: thalassaemia carrier, capillary electrophoresis




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