Pathophysiology and Treatment of Nonsteroidal Anti-inflammatory Drug Gastropathy

Fandy Gosal, Bram Paringkoan, Nelly Tendean Wenas

Abstract


Gastropathy nonsteroidal anti-inflammatory drugs (NSAID) is a gastric mucosal lesions associated with NSAID used. The mechanisms of NSAID induced gastropathy due to topical damage caused by ion trapping of NSAID in gastric mucosa and systemic effect by inhibiting cyclooxygenase (COX) which causes inhibition of prostaglandins synthesis. Prevention and treatment of gastropathy NSAID consist of cessation of NSAID, selection of NSAID, and the use of gastroprotective drugs with gastrointestinal and cardiovascular risks consideration. J Indon Med Assoc. 2012;62:444-9.

Keywords: gastropathy, NSAID, pathophysiology, treatment


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