Effect of clomiphene citrate on the quality of cervical mucus in infertile women

Elizabeth Catherine Jusuf

Abstract


Objective: To describe the effect of clomiphene citrate on the quality of cervical mucus in infertile women.

Method: This study is a non-randomized clinical trial. The study was carried out at several education hospitals in Makassar from March 2008 to April 2009. The subjects of the study were infertile women who fulfilled the inclusion criteria with intervention study. The statistical analysis was performed using Wilcoxon Sign-ed Rank Test with α 5%.

Result: There were 36 cases found, and most were in the range of 26 - 30 years old (38.9%), university level education (50%), civil servant (47.2%), normal nutritionals status (55.5%), regular menstruation cycle (94.4%), marriage length 1 - 5 years (52.8%), and previously treated (61.1%). There was a significant difference of the cervical mucus quality in the infertile women before and after the administration of clomiphene citrate which tend to become worse (p = 0.012). At previously CC-treated group, it was found that after the administration of clomiphene citrate, the quality of cervical mucus tend to be worse (100%).

Conclusion: The administration of clomiphene citrate tends to have declining effect on cervical-mucus quality of infertile women.

[Indones J Obstet Gynecol 2010; 34-2: 73-6]

Keywords: clomiphene citrate, quality of cervical mucus, infertile women

 

Tujuan: Untuk mengetahui pengaruh pemberian klomifen sitrat terhadap kualitas getah serviks perempuan infertil.

Metode: Penelitian ini merupakan Non-Randomized Clinical Trial. Dilakukan pada beberapa rumah sakit pendidikan di Makassar dari Maret 2008 sampai April 2009. Subjek penelitian adalah perempuan infertil yang memenuhi kriteria inklusi yang merupakan studi intervensi. Analisis statistik dengan menggunakan Wilcoxon Signed Rank Test dengan α 5%.


Hasil: Didapatkan 36 kasus perempuan infertil, dengan karakteristik terbanyak pada usia 26 - 30 tahun (38,9%), pendidikan setingkat perguruan tinggi (50%), pekerjaan PNS (47,2%), status gizi normal (55,5%), siklus haid teratur (94,4%), lama menikah 1 - 5 tahun (52,8%), riwayat pernah berobat (61,1%). Perubahan kualitas getah serviks sebelum dan setelah pemberian klomifen sitrat cenderung menjadi jelek (p = 0,012). Pada kelompok yang pernah berobat, didapatkan perubahan kualitas getah serviks yang menjadi jelek setelah pemberian klomifen sitrat (100%).

Kesimpulan: Pemberian klomifen sitrat menyebabkan penurunan kualitas getah serviks perempuan infertil.

[Maj Obstet Ginekol Indones 2010; 34-2: 73-6]

Kata kunci: klomifen sitrat, kualitas getah serviks, perempuan infertil


References



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