SUB-CHRONIC TOXICITY TEST KEMBANG SUNGSANG LEAF EXTRACT (Gloriosa superba L.) ON RENAL FUNCTION OF WHITE RATS

M. Wien Winarno, Dian Sundari

Abstract


Kembang sungsang (Gloriosa superba L.) including families Colchicaceae,
empirically this plant can be used to treat gout, diuretic, rheumatic and cultivated
because of its use. All parts of this plant contain alkaloids called colchichin and gloriosin
and most found on the tuber. From the results of previous research, the ethanol extract of
leaves and flowers antihiperurisemia Breech is included in the class materials
"Practically Non-Toxic." However, repeated administration may cause toxic effects on
body organs.  Test the effect of 70% ethanol extract of  kembang sungsang leaves of
kidney function in male and female white rats. There are 3 (three) doses of test materials
which are: 32.25 mg, 21.5 mg and 14.35 mg/100 g bw., And as a control was distilled
water. Test and control material was administered orally in accordance with a
predetermined time is 45 days, 90 days and 104 days (recovery period for the largest
dose) administration. Observation is done by sacrificing mice according to given
deadlines. Results of blood biochemistry analysis showed that drug therapy for 45 days,
to increase blood urea and creatinine, but the award of 90 and 104 days (recovery)
decreased creatinine levels.

Keywords: Toxicity, Kembang Sungsang, Gloriosa superba L. Kidney function


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